Ritalin

Methylphenidate (Ritalin) is a medication prescribed for individuals (usually children) who have an abnormally high level of activity or attention-deficit hyperactivity disorder (ADHD). According to the National Institute of Mental Health, about 3 to 5 percent of the general population has the disorder, which is characterized by agitated behavior and an inability to focus on tasks. Methylphenidate also is occasionally prescribed for treating narcolepsy.

Health Effects

Methylphenidate is a central nervous system (CNS) stimulant. It has effects similar to, but more potent than, caffeine and less potent than amphetamines. It has a notably calming effect on hyperactive children and a "focusing" effect on those with ADHD.

Recent research1 at Brookhaven National Laboratory may begin to explain how methylphenidate helps people with ADHD. The researchers used positron emission tomography (PET - a noninvasive brain scan) to confirm that administering normal therapeutic doses of methylphenidate to healthy, adult men increased their dopamine levels. The researchers speculate that methylphenidate amplifies the release of dopamine, a neurotransmitter, thereby improving attention and focus in individuals who have dopamine signals that are weak, such as individuals with ADHD.

When taken as prescribed, methylphenidate is a valuable medicine. Research shows that people with ADHD do not become addicted to stimulant medications when taken in the form prescribed and at treatment dosages.2 Another study found that ADHD boys treated with stimulants such as methylphenidate are significantly less likely to abuse drugs and alcohol when they are older than are non-treated ADHD boys.3

Because of its stimulant properties, however, in recent years there have been reports of abuse of methylphenidate by people for whom it is not a medication. Some individuals abuse it for its stimulant effects: appetite suppression, wakefulness, increased focus/attentiveness, and euphoria. When abused, the tablets are either taken orally or crushed and snorted. Some abusers dissolve the tablets in water and inject the mixture - complications can arise from this because insoluble fillers in the tablets can block small blood vessels.

Trends in Ritalin Abuse

At their June 2000 meeting, members of NIDA's Community Epidemiology Work Group (CEWG)* shared the following information.

The abuse of methylphenidate has been reported in Baltimore, mostly among middle and high schools students; Boston, especially among middle and upper-middle class communities; Detroit; Minneapolis/St. Paul; Phoenix; and Texas.

When abused, methylphenidate tablets are often used orally or crushed and used intranasally.

In 1999, 165 methylphenidate-related poison calls were made in Detroit; 419 were reported in Texas, with 114 of those involving intentional misuse or abuse.

On Chicago's South Side, some users inject methylphenidate (this is referred to as "west coast"). Also, some mix it with heroin (a "speedball") or in combination with both cocaine and heroin for a more potent effect.

Because stimulant medicines such as methylphenidate do have potential for abuse, the U.S. Drug Enforcement Administration (DEA) has placed stringent, Schedule II controls on their manufacture, distribution, and prescription. For example, DEA requires special licenses for these activities, and prescription refills are not allowed. States may impose further regulations, such as limiting the number of dosage units per prescription.

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